US 6,559,293
| Title: Topiramate Sodium Trihydrate Licensed to J&JPRDDescription: This patent claims a sodium trihydrate salt of the drug topiramate. The free acid form of topiramate is currently approved in the United States for the treatment of epilepsy and is sold under the tradename Topamax®. This patent has been assigned to Ortho-McNeil Pharmaceutical, Inc. |
US 6,699,840
| Title: Controlled or Delayed Release Forms of Topiramate Licensed to J&JPRDDescription: This patent claims a controlled or delayed release form of topiramate sodium trihydrate salt. The free acid form of topiramate is currently approved in the United States for the treatment of epilepsy and is sold under the tradename Topamax®. This patent has been assigned to Ortho-McNeil Pharmaceutical, Inc. |
US 6,758,099
| Title: System and Method for Optimizing Tissue Barrier Transfer of Compounds
Description: The present invention relates to high-throughput systems and methods to prepare a large number of component combinations, at varying concentrations and identities, at the same time, and high-throughput methods to test tissue barrier transfer, such as transdermal transfer, of components in each combination. The methods of the present invention allow determination of the effects of inactive components, such as solvents, excipients, enhancers, adhesives and additives, on tissue barrier transfer of active components, such as pharmaceuticals. The invention thus encompasses the high-throughput testing of pharmaceutical compositions or formulations in order to determine the overall optimal composition or formulation for improved tissue transport, such as transdermal transport. |